Mupirocin Nanofibers For Treatment Of Secondary burns

The aims of the research work were (1) preparation and evaluation of nanofibers using mupirocin for treating primary and secondary burns by solvent casting method. (2) Preparation and evaluation of nanofibers using mupirocin for treating primary and secondary burns by electrospinning method. (3) Comparison of both the methods used for preparation of nanofibers for better and efficient treatment of burns. In this study we had used mupirocin for the treatment of burn. This study estimated the topical potential of nanofibers incorporated with mupirocin for treating burns, to compare traditional and modern methods of preparation. Nanofibers of mupirocin were composed of various ratio's of Polyvinyl Pyrollidone, Gelatin Type-A, and Ethanol using two methods- Solvent casting and Electrospinning. The nanofibers prepared through Electrospinning technique showed better antibacterial activity against Staphyllococcus aureus as compared to the nanofiber prepared through Solvent Casting technique This study suggested that mupirocin incorporated nanofibers could be a potent topical drug delivery system to treat burns.