Death Receptors and Cognate Ligands in Cancer

Death Receptors and Cognate Ligands in Cancer

AngličtinaMäkká väzbaTlač na objednávku
Springer, Berlin
EAN: 9783642260766
Tlač na objednávku
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Podrobné informácie

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.

Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.

This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

EAN 9783642260766
ISBN 3642260764
Typ produktu Mäkká väzba
Vydavateľ Springer, Berlin
Dátum vydania 14. marca 2012
Stránky 280
Jazyk English
Rozmery 235 x 155
Krajina Germany
Čitatelia Professional & Scholarly
Ilustrácie XIV, 280 p. 20 illus., 9 illus. in color.
Editori Kalthoff Holger
Edícia 2009 ed.
Séria Results and Problems in Cell Differentiation